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Title :

Metabolic Network Model for Escherichia coli

Description :

Metabolic maps provide a framework for studying the consequences of genotype changes and the relationships between genotypes and phenotypes. This metabolic network model for Escherichia coli incorporated data on 436 metabolic intermediates undergoing 720 possible enzyme-catalyzed reactions. In this diagram, the circles contain abbreviated names of the metabolic intermediates, and the arrows represent enzymes. The very heavy lines indicate links with high metabolic fluxes. Analyses were correct 90% of the time in predicting the ability of 36 mutants with single-gene deletions to grow on different media. [adapted from J.S. Edwards and B.O. Palsson, Proc. Nat. Acad. Sci. 97, 5528­33 (2000)]

Citation :

Genomes to Life Program Roadmap, April 2001, DOE/SC-0036, U.S. Department of Energy Office of Science, http://genomicscience.energy.gov/.

Credit or Source :

Genome Management Information System, Oak Ridge National Laboratory

Hi Res :

High-Resolution Image


Image Use and Credits
Almost all the images on these pages are original graphics created by the U.S. Department of Energy Genome Program's Genome Management Information System (GMIS). You will recognize GMIS images by their credit line. Permission to use these graphics is not needed, but please credit the U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov. All other images were provided by third parties and not created by the U.S. Department of Energy. You must contact the person listed in the credit line before using those images.

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